Brain Blood Vessel Responses to Changes in Blood Flow
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age55-69
SponsorUniversity of Wisconsin, Madison
About this trial
Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.
Eligibility criteria
Qualifiers
Between the ages of 55-69 years
Have a BMI less than or equal to 34.5 kg/m2
Nonsmoker
are less than 72 in (182.88 cm) height
Disqualifiers
Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
Uncontrolled hypertension
Trial design
Treatments tested in this trial
- MRI
- Prazosin
- Placebo
Treatment groups
36 Participants
are divided into 1 treatment groupSponsors and collaborators
University of Wisconsin, Madison
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
Source ClinicalTrials.gov