Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age20-40
SponsorUniversity of Wisconsin, Madison
About this trial
Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.
Eligibility criteria
Qualifiers
Between the ages of 20-40 years
Have a BMI ≤34.5 kg/m2
are less than 72 in (182.88 cm) height
Nonsmoker
Disqualifiers
Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
Uncontrolled hypertension
Trial design
Treatments tested in this trial
- MRI
- Prazosin
- Placebo
Treatment groups
36 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov