The purpose of this research is to determine whether treatment with the study drug dapagliflozin for 3 months affects peripheral venous pressure at rest and during exercise in adults with failing Fontan circulation.
Signed informed consent prior to any study specific procedures
History of Fontan procedure
Male or female subject
Age ≥ 18
Type I diabetes
Any of the following medications: Insulin or Pramlintide, Sandostatin, Akeega (abiraterone acetate), Growth Hormone (Somatogrogon-GHLA), Lithium, Chloroquine, Hydroxychloroquine, Thioctic acid (alpha lipoic acid), Empagliflozin or Canagliflozin
Recent hospitalization (<30 days) or revascularization (<90 days)
Significant valvular heart disease (≥moderate stenosis, >moderate regurgitation)