Cardiac MRI-guided Deferiprone Therapy for Acute Myocardial Infarction Patients

ConditionAcute Myocardial Infarction Type 1

Trial statusRecruiting

Trial phasePhase 2

Trial typeInterventional

Biological sexAll

Age18-79

SponsorRohan Dharmakumar

About this trial

The objective of this randomized, controlled pilot study is to determine the efficacy of Deferiprone to reduce the amount of free iron inside the hemorrhagic zone of myocardial infarction among hemorrhagic myocardial infarction patients.

Eligibility criteria

Qualifiers

Age 18-79 years

Index Anterior wall STEMI

Emergency coronary angiogram with primary PCI

Disqualifiers

Prior history of MI / PCI / coronary artery bypass graft (CABG) within previous 1 year

Patients with previous history of left ventricular ejection fraction (LVEF) < 40%

Use of investigational drugs or devices 30 days prior to randomization

Known allergy or contra-indication to gadolinium/contrast agents

Trial design

Treatments tested in this trial

Deferiprone Tablets
Placebo

Treatment groups

89 Participants

are divided into 4 treatment groups

Sponsors and collaborators

Rohan Dharmakumar

Lead sponsor

Indiana University

Sponsor institution

Minneapolis Heart Institute

Collaborator

Source ClinicalTrials.gov