CBD Knee Osteoarthritis Study

ConditionOsteoarthitis
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age21+
SponsorUniversity of Tennessee

About this trial

Osteoarthritis of the knee is a common cause of pain in the US. The currently available medicines for knee osteoarthritis sometimes are not effective at relieving the pain or have unacceptable side effects. Thus, alternate pain relieving treatments are needed.

CBD, an active chemical from the hemp derived cannabis sativa plant, has received a lot of attention for its potential pain relieving properties, but there has been limited research to find out if topically applied CBD can decrease pain from knee osteoarthritis. CBD lacks the psychoactive effects seen with marijuana use, because it does not contain THC which is responsible for those effects in marijuana. It is legal to use CBD in the State of Tennessee (site of study).

The CBD Knee Study is sponsored by the University of Tennessee Health Science Center and is a collaborative effort between doctors at UT and Campbell Clinic. In the CBD Knee Study, the investigators are examining whether topically applied CBD dissolved in Castor Oil will relieve knee pain in persons with knee osteoarthritis.

Persons who take part in the study would need to come for study visits, fill out questionnaires about their health and knee pain, and would be asked to use the topical study oil on their knees. Taking part in the CBD Knee Study is voluntary.

Eligibility criteria

Qualifiers

Knee OA (grade 2-3 as measured by the Kellgren-Lawrence Classification)

OA knee pain on the Visual Analog Pain Scale > 4 in either knee

Receiving treatment at one of the eight Campbell Clinic Orthopaedics locations

Disqualifiers

Other forms of arthritis such as psoriatic arthritis or rheumatoid arthritis due to different sources of inflammation in these conditions

Allergies to CBD or Castor Oil

Current opioid use

BMI of over 40

Trial design

Treatments tested in this trial

  • Cannabidiol (CBD)
  • Castor Oil (Placebo)

Treatment groups

30 Participants
are divided into 2 treatment groups

Sponsors and collaborators