About this trial
This study aims to determine the value of cluster of differentiation (CD70)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging for diagnosing human malignancies, including renal cell carcinoma (particularly clear cell renal cell carcinoma), lymphoma, and nasopharyngeal carcinoma (NPC), among others.
Eligibility criteria
Qualifiers
Aged 18-80 year-old and of either sex;
Histologically confirmed diagnosis of renal cancer (especially ccRCC)/lymphoma/NPC or suspected renal cancer/lymphoma/NPC by diagnostic imaging;
Capable of giving signed informed consent, including compliance with the requirements and restrictions in the informed consent form (ICF) and this protocol.
Disqualifiers
Pregnancy;
Severe hepatic and renal insufficiency;
Allergic to single-domain antibody radiopharmaceuticals.
Trial design
Treatments tested in this trial
- [18F]F-RESCA-RCCB6
- [18F]F-RESCA-R8B4
- [68Ga]Ga-NOTA-R8B4
- [18F]F-RESCA-RD06
- [68Ga]Ga-NOTA-RD06