CD70-targeted immunoPET Imaging of Malignant Cancers

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorRenJi Hospital

About this trial

This study aims to determine the value of cluster of differentiation (CD70)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging for diagnosing human malignancies, including renal cell carcinoma (particularly clear cell renal cell carcinoma), lymphoma, and nasopharyngeal carcinoma (NPC), among others.

Eligibility criteria

Qualifiers

Aged 18-80 year-old and of either sex;

Histologically confirmed diagnosis of renal cancer (especially ccRCC)/lymphoma/NPC or suspected renal cancer/lymphoma/NPC by diagnostic imaging;

Capable of giving signed informed consent, including compliance with the requirements and restrictions in the informed consent form (ICF) and this protocol.

Disqualifiers

Pregnancy;

Severe hepatic and renal insufficiency;

Allergic to single-domain antibody radiopharmaceuticals.

Trial design

Treatments tested in this trial

  • [18F]F-RESCA-RCCB6
  • [18F]F-RESCA-R8B4
  • [68Ga]Ga-NOTA-R8B4
  • [18F]F-RESCA-RD06
  • [68Ga]Ga-NOTA-RD06

Treatment groups

300 Participants
are divided into 1 treatment group

Sponsors and collaborators