The goal of this study is to find out if the antihistamine, clemastine, can make the white matter in the brain better in older adults with depression. The study will also determine whether this improvement can make antidepressant treatment work better, reduce depressive symptoms, and improve memory and thinking.
Age > 60 years
Diagnosis of major depressive disorder, single or recurrent episode (DSM5)
Symptom Severity: MADRS ≥ 15
Seeking antidepressant treatment
Other Axis I psychiatric disorders, except for simple phobia or anxiety disorders present uniquely during the depressive episode (e.g., generalized anxiety disorder (GAD) or panic disorder symptoms)
History of alcohol or drug dependence or abuse in the last year
History of a developmental disorder or history of IQ (intelligence quotient) <70
Acute suicidality ideation within the past month as determined by the Columbia Suicide Severity Rating Scale (C-SSRS)
University of Illinois at Chicago
Lead sponsor
Cures Within Reach
Collaborator