The following issues warrant in-depth investigation: further refinement of staging by primary tumor site, the increasing prognostic weight of T classification, risk assessment for lymph node metastasis and postoperative recurrence/distant metastasis, and whether NET G3 with poor prognosis requires more aggressive postoperative intervention. This study plans to enroll patients classified as Stage III according to the AJCC 9th Edition staging system, including NET G1/G2 and all G3 patients, for a clinical trial on postoperative adjuvant therapy.
Provide written informed consent and voluntarily participate in the study.
Aged 18-80 years, male or female.
Confirmed as Stage III NET G1/G2 or any-stage NET G3 after surgical treatment.
Other postoperative NET patients deemed by the investigator to have high-risk factors.
Major surgery, open biopsy, or significant trauma within 28 days prior to the first dose.
History of severe or poorly controlled interstitial lung disease.
Poorly controlled hypertension (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) despite antihypertensive medication.
Significant bleeding tendency or clinically significant bleeding within 3 months prior to the first dose (e.g., gastrointestinal bleeding, hemorrhagic gastric ulcer, vasculitis).