About this trial
This is a prospective, single arm, multicenter study to evaluate the safety and efficacy of CMOP±R in patients with newly diagnosed non-Hodgkin's lymphoma.
Eligibility criteria
Qualifiers
Patients fully understand this study, voluntarily participate and sign the informed consent (ICF);
Age: 18-75 years old;
Expected survival time ≥ 3 months;
Histopathologically diagnosed newly diagnosed non-Hodgkin's lymphoma;
Disqualifiers
Subjects have previously received anthracyclic drug pretreatment;
Hypersensitivity to any study drug or its components;
Uncontrollable systemic diseases (such as advanced infection, uncontrollable hypertension, diabetes, etc.);
Heart function and disease meet one of the following conditions: a) long QTc syndrome or QTc interval >480 ms; b) complete left bundle branch block, grade II or III atrioventricular block; c) Serious and uncontrolled arrhythmias requiring drug treatment; d) New York Heart Association grade ≥ III; e) Cardiac ejection fraction (LVEF) lower than 50%;f) A history of myocardial infarction, unstable angina pectoris, severe unstable ventricular arrhythmia or any other arrhythmia requiring treatment, a history of clinically serious pericardial disease, or ECG evidence of acute ischemia or active conduction system abnormalities within 6 months before recruitment.
Trial design
Treatments tested in this trial
- CMOP±R