CMOP±R in the Treatment of Untreated Non-Hodgkin's Lymphoma

ConditionNHL
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorThe First Affiliated Hospital of Soochow University

About this trial

This is a prospective, single arm, multicenter study to evaluate the safety and efficacy of CMOP±R in patients with newly diagnosed non-Hodgkin's lymphoma.

Eligibility criteria

Qualifiers

Patients fully understand this study, voluntarily participate and sign the informed consent (ICF);

Age: 18-75 years old;

Expected survival time ≥ 3 months;

Histopathologically diagnosed newly diagnosed non-Hodgkin's lymphoma;

Disqualifiers

Subjects have previously received anthracyclic drug pretreatment;

Hypersensitivity to any study drug or its components;

Uncontrollable systemic diseases (such as advanced infection, uncontrollable hypertension, diabetes, etc.);

Heart function and disease meet one of the following conditions: a) long QTc syndrome or QTc interval >480 ms; b) complete left bundle branch block, grade II or III atrioventricular block; c) Serious and uncontrolled arrhythmias requiring drug treatment; d) New York Heart Association grade ≥ III; e) Cardiac ejection fraction (LVEF) lower than 50%;f) A history of myocardial infarction, unstable angina pectoris, severe unstable ventricular arrhythmia or any other arrhythmia requiring treatment, a history of clinically serious pericardial disease, or ECG evidence of acute ischemia or active conduction system abnormalities within 6 months before recruitment.

Trial design

Treatments tested in this trial

  • CMOP±R

Treatment groups

197 Participants
are divided into 1 treatment group

Locations

This trial has no locations