Combination Therapy of AK112 With Chemotherapy and/or Olaparib in Platinum-sensitive Ovarian Cancer

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18+
SponsorAkeso

About this trial

An Exploratory, Multi-cohort Phase II Study of combination therapy of AK112 with chemotherapy and/or olaparib in platinum-sensitive ovarian cancer(PSOC)

Eligibility criteria

Qualifiers

Signs the written informed consent form.

Female participants who are at least 18 years of age on the day of signing informed consent with.

ECOG of 0 or 1.

Life expectancy ≥3 months.

Disqualifiers

Other pathological types such as mucinous cancer, sex cord stromal cell tumor, etc.

Presence of central nervous system (CNS) metastases or carcinomatous meningitis.

Subjects with uncontrollable pleural, pericardial, or peritoneal effusion requiring repeated drainage.

Subjects with other active malignancies within 3 years prior to randomization.

Trial design

Treatments tested in this trial

  • AK112 low dose
  • Chemotherapy
  • Olaparib
  • AK112 high dose

Treatment groups

150 Participants
are divided into 5 treatment groups

Sponsors and collaborators