This study evaluates whether the combined treatment of methylphenidate and non-invasive brain stimulation, called intermittent theta burst stimulation, can effectively treat apathy in individuals with Alzheimer's disease or mixed AD/vascular dementia
Alzheimer's disease or mixed Alzheimer's disease and vascular disease
MMSE score 10-28 inclusive
Clinically significant apathy
Stable dose of psychotropic medication
Major Depressive Episode
Clinically significant agitation, delusions, hallucinations
Currently talking a dopaminergic agent other than methylphenidate
Failure to clear the TMS adult safety scale (e.g. unapproved pacemakers, metallic implants, history of epilepsy)
Sunnybrook Health Sciences Centre
Lead sponsor
Alzheimer Society of Canada
Collaborator
Sunnybrook Research Institute
Collaborator
Brain Canada
Collaborator