Comparing the Effect of siSPARC Microneedle Patch Versus siSPARC+siLR4A Microneedle Patch on Post-surgical Scars
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age21-75
SponsorNational Skin Centre
About this trial
This randomized, double-blind controlled study aims to compare the effect on appearance of post- surgical scars between daily application of siSPARC microneedle patch versus siSPARC + siLR4A microneedle patches. These are patches comprising short microneedles embedded with hydrolysed RNA (siRNAs).
Eligibility criteria
Qualifiers
Adult
Age 21-75
2 weeks (+/- 7 days) after surgical operation with incision into the dermis
Post-stitch removal when stitches were applied
Disqualifiers
Pregnant or lactating participant
Participants with wound infection
Participants assessed to be uncooperative or unable to self-administer the interventions
Participants with known contact allergy to ingredients in the patch formulation (comprising hyaluronic acid, siRNA and glue) and/or isopropyl alcohol
Trial design
Treatments tested in this trial
- siSPARC + siLR4A microneedle patches
- siSPARC microneedle patch
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov