Control Systems Engineering for Weight Loss Maintenance

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-70
SponsorThe Miriam Hospital

About this trial

This project capitalizes on principles of control systems engineering to build a dynamical model that predicts weight change during weight loss maintenance using behavioral, psychosocial, and environmental indicators evaluated in a system identification experiment. A 6-month behavioral obesity treatment will be administered to produce weight loss. Participants losing at least 3% of initial body weight will be followed for an additional 12 months via daily smartphone surveys that incorporates passive sensing to objectively monitor key behaviors. Survey data pertaining to behavioral, psychosocial, and environmental indicators will be used to develop a controller algorithm that can predict when an individual is entering a heightened period of risk for regain and why risk is elevated. Interventions targeting key risk indicators will be randomly administered during the system ID experiment. Survey and passive sensing data documenting the effects of the interventions will likewise drive development of the controller algorithm, allowing it to determine which interventions are most likely to counter risk of regain.

Eligibility criteria

Qualifiers

English language fluent and literate at the 6th grade level

Body mass index (BMI) between 25 and 50 kg/m-squared

Able to walk 2 city blocks without stopping

Owns a smartphone

Disqualifiers

Report of a heart condition, chest pain during periods of activity or rest, or loss of consciousness in the 12 months prior to enrolling.

Currently participating in another weight loss program

Currently taking weight loss medication

Has lost ≥5% of body weight in the 6 months prior to enrolling

Trial design

Treatments tested in this trial

  • Intervention Targeting Stress and Emotion Regulation
  • Intervention Targeting Motivation and Self-efficacy for Weight Management
  • Intervention for Normalization of Eating
  • Intervention Targeting Physical Activity and Sleep

Treatment groups

180 Participants
are divided into 1 treatment group

Sponsors and collaborators

The Miriam Hospital

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator