The purpose of this study is to To confirm the predictive value of CCND1 for TPF induction in cN2 patients with OSCC
Age: 18 to 75 years old.
Sex: both males and females.
Karnofsky performance status (KPS) >60.
Histological biopsy confirming squamous cell carcinoma of the oral cavity (tongue, gingiva, buccal mucosa, floor of mouth, palate, and retromolar region).
Evidence of distant metastatic disease and other cancers.
Surgical procedure of the primary tumors or lymph nodes (except diagnostic biopsy).
Previous radiotherapy or chemotherapy.
Other previous malignancies within 5 years.