Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorNational Cancer Institute, Egypt
About this trial
The goal of this clinical trial is to learn if drugs as cyclophosphamide (C) and etoposide (E) work to treat advanced head and neck cancer in adults. It will also learn about the safety of both drugs. The main questions it aims to answer are:
Do drugs C and E work to treat advanced head and neck cancer, after failure on first line chemotherapy? What medical problems do participants have when taking drugs C and E? Researchers will compare drugs C and E in combination to a placebo (a look-alike substance that contains no drug) to see if these 2 drugs works to treat advanced head and neck cancer.
Participants will:
Take drug C every 3 weeks and drug E every 4 weeks or a placebo every week for 6 months.
Visit the clinic once every 3 weeks for checkups and tests. Keep a diary of their symptoms.
Eligibility criteria
Qualifiers
Adult participants, age = or > 18 years
Participants with recurrent head and neck squamous cell carcinoma after failure on first line chemotherapy.
Participants with advanced progressed, resistant, metastatic head and neck squamous cell carcinoma.
Disqualifiers
Adjuvant and Neoadjuvant head and neck squamous cell carcinoma patients.
Trial design
Treatments tested in this trial
- Cyclophosphamide and Etoposide in combination
- Methotrexate
Treatment groups
120 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov