Dark Adaptation as an Early Indicator of Response to Statin Therapy for Intermediate AMD

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age50-85
SponsorMassachusetts Eye and Ear Infirmary

About this trial

interventional trial for off label use of high dose atorvastatin 80 mg in intermediate AMD patients and correlate recovery response measured by dark adaptation recovery time with drusen volume reduction measured by SD-OCT

Eligibility criteria

Qualifiers

All subjects with intermediate AMD diagnosis in one or both eyes will be considered, regardless the severity stage and subtype of disease in the other eye.

Disqualifiers

Patient previously taking high dose Atorvastatin 80 mg

Patients previously taking other statins than high dose atorvastatin, in whom primary care provider (PCP) feels cannot be safely moved to high dose atorvastatin or those in which high dose atorvastatin is deemed contraindicated by PCP

Patients with known adverse reaction to statins

Patients with severe renal disease or multiple comorbidities

Trial design

Treatments tested in this trial

  • Atorvastatin 80mg

Treatment groups

21 Participants
are divided into 1 treatment group