Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery
ConditionDelirium - Postoperative
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age55-70
SponsorBenha University
About this trial
This study evaluates the dose-response relationship of Dexmedetomidine (DEX) in reducing the incidence and severity of postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) in elderly patients. The study compares different doses of DEX against a fentanyl control group in patients undergoing major lower limb orthopedic surgery under general anesthesia to determine the optimal dosage for cognitive protection.
Eligibility criteria
Qualifiers
Elderly surgical patients.
ASA physical status grade II-III.
Planned major lower limb orthopedic surgery.
Disqualifiers
pre-existing dementia or drug allergies
Trial design
Treatments tested in this trial
- Dexmedetomidine (Low dose)
- Dexmedetomidine (High dose)
- Fentanyl
Treatment groups
75 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov