This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched healthy controls.
Adult healthy volunteers
Matched for age, sex, BMI, and oestrogen replacement/menopause/hormonal contraceptives to patients.
No medication, except hormonal contraception
Adult patients with a confirmed diagnosis of AVP deficiency based on accepted criteria6
Participation in a trial with investigational drugs within 30 days
Active substance use disorder within the last six months
Consumption of alcoholic beverages >15 drinks/week
Current or previous psychotic disorder (e.g., schizophrenia spectrum disorder)