Effect of Ipratropium Bromide on EILO
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age8-17
SponsorCook Children's Health Care System
About this trial
The investigators propose a study that compares breathlessness and airway obstruction during intense exercise in 34 children and adolescents with Exercise-Induced Laryngeal Obstruction after breathing in ipratropium bromide or placebo. It is hypothesized that breathlessness and airway obstruction will be lower following breathing in ipratropium bromide compared with placebo.
Eligibility criteria
Qualifiers
Patients must be diagnosed with EILO confirmed by Continuous Laryngoscopy During Exercise
Patients must be able to complete exercise testing
Patients must report dyspnea
Patients must have given assent with parental consent, understand all study procedures, and comply with them for the entire length of the study.
Disqualifiers
Patients that do not have EILO.
Patients who did not undergo diagnostic CPET with CLE.
Patients with hypersensitivity to atropine or its derivatives due to structural similarity with ipratropium bromide.
Patients with a history of atrial flutter and/or fibrillation
Trial design
Treatments tested in this trial
- Ipratropium Bromide
- Normal Saline (Placebo)
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov