International travel disrupts gut health through dietary changes, microbial exposure, and stress, often causing gastrointestinal symptoms like traveler's diarrhea and sleep disturbances. These shifts may increase antibiotic resistance risks. Probiotics may help stabilize gut microbiota and improve well-being during travel. This randomized, double-blind, placebo-controlled trial investigated whether probiotic supplementation mitigates gut microbiota perturbations, gastrointestinal symptoms, and sleep issues in adults traveling abroad. The investigators also assessed changes in anxiety, well-being, gut immunity, microbial function, and antibiotic resistance genes.
Generally healthy adults
Scheduled to undertake a short-term round trip (less than 7 days) to abroad
Able to complete study procedures
Willing to take intervention products
Use of antibiotics, probiotics, hormones, immunosuppressants, biologics or JAK inhibitors within four weeks prior to study
Chronic or severe systemic diseases (including cardiovascular, hepatic, renal, malignant or psychiatric disorders)
Uncontrolled parasitic infections
Long-term use of corticosteroids, growth hormone, vitamin B12, lysine or inositol
Universiti Sains Malaysia
Lead sponsor
Tsinghua University Science and Technology
Collaborator