Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus
ConditionOral Lichen Planus
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorCairo University
About this trial
Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to provide clinical evidence on the efficacy of bromelain for managing OLP, potentially offering a safer and more effective treatment option.
Eligibility criteria
Qualifiers
Patients suffering from symptomatic OLP
Patients free from any visible oral lesions other than OLP.
Patients who agreed to take the supplied interventions.
Patient who will agree to participate in the study.
Disqualifiers
Patients suffering from any systemic disease.
Treatment with any systemic treatment such as systemic steroids, other immunosuppressive drugs or non-steroidal anti-inflammatory drugs at least eight weeks.
Treatment with any oral topical medications for at least four weeks prior to the study.
Pregnant and lactating mothers.
Trial design
Treatments tested in this trial
- Topical Bromelain
- 0.1% topical triamcinolone acetonide
- Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase
Treatment groups
42 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov