Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-60
SponsorCairo University

About this trial

Bromelain, a natural product, exhibits anti-inflammatory, immunomodulatory, and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to evaluate the effect of bromelain as a safe alternate for management of RAS.

Eligibility criteria

Qualifiers

Adults aged 18-60 years.

Diagnosed with RAS.

Onset of ulcer within the last 48 hours.

Willingness to participate and provide informed consent.

Disqualifiers

History of hematological deficiencies, GIT disorders, Behcet's disease and major systemic diseases.

Pregnant or breastfeeding patients.

Previous treatment for the current ulcer episode.

Trial design

Treatments tested in this trial

  • 35% Topical Bromelain in Orabase
  • 50% Topical Bromelain in Orabase
  • 0.1% Topical Triamcinolone Acetonide in Orabase

Treatment groups

63 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators