About this trial
The objective of this clinical trial is to determine whether α-tocopherol (vitamin E) supplementation decreases inflammation and clinical activity in patients with rheumatoid arthritis (RA).The main questions to be answered are:
* Is supplementation with vitamin E (α-tocopherol) for one month associated with decreased clinical activity and inflammation in patients with RA?
Researchers will compare α-tocopherol with a placebo (a look-alike substance containing no active ingredient) to see if α-tocopherol effectively reduces inflammation and clinical activity in patients with rheumatoid arthritis.
Participants will:
* Take two capsules (one in the morning and one in the afternoon) of either α-tocopherol or placebo every day for a month. * Attend clinic visits at the start of the intervention (baseline) and at the end of the month for final check-ups and tests. * Keep a diary to record your symptoms and how often you take α-tocopherol or placebo.
Eligibility criteria
Qualifiers
Female sex
RA classification (ACR/EULAR 2010)
Early RA 2 years
Treatment with conventional synthetic FARMEs (Metrotexato, Hydroxychloroquine, Leflunomide, Sulfasalazina and their combinations)
Disqualifiers
Liver and kidney disease
Overlap syndrome
Coagulation disorders
Pregnancy
Trial design
Treatments tested in this trial
- Will take vitamin E 800mg/day
- Will take 200mg/day magnesium oxide placebo.
Treatment groups
Sponsors and collaborators
University of Guadalajara
Lead sponsor
Hospital Civil de Guadalajara
Collaborator