Evaluating the safety and effectiveness of a CD25 monoclonal antibody-based prophylactic acute graft-versus-host-disease (aGVHD) regimen following unrelated umbilical cord blood transplantation (UCBT) for malignant hematologic disorders in reducing severe aGVHD.
Malignant hematologic disorders;
Patients undergoing UCBT;
Female patients of childbearing potential must have a negative pregnancy test and agree to use effective contraception during treatment and for the following year.
Non-malignant hematologic disorders;
History of allogeneic hematopoietic stem cell transplantation or solid organ transplantation;
Uncontrolled bacterial, viral, or fungal infections. "Uncontrolled" is defined as lack of clinical improvement or progression despite adequate antimicrobial therapy;
HIV infection or active hepatitis B or C virus infection;