Effects of an Antioxidant Supplement on Blood Vessel Health
ConditionHealthy
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity of Georgia
About this trial
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysfunction in healthy NHB adults.
Eligibility criteria
Qualifiers
Self-identify as either non-Hispanic Black or non-Hispanic White.
Men and women 18-75 years old.
Non-hypertensive (systolic blood pressure [SBP]<130 and diastolic blood pressure [DBP] <85 mmHg).
Have low density lipoprotein cholesterol <150mg/dl.
Disqualifiers
Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders)
Known skin allergies to latex or adhesives
Smoking and/or use of nicotine-containing products within the past year
Use of illegal/recreational drugs
Trial design
Treatments tested in this trial
- MitoQ
- Placebo
- MitoTempo
- Tempol
- L-NAME
- SNP - Sodium Nitroprusside
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov