Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder
ConditionOpioid Use Disorder
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age21-60
SponsorWayne State University
About this trial
This preliminary study is designed to evaluate mechanisms by which excitatory dorsolateral prefrontal cortex (dlPFC) repetitive transcranial magnetic stimulation (rTMS) (vs. sham) and pharmacological stress (vs. placebo) alter behavior in non-treatment seeking individuals with opioid use disorder (OUD). Specific Aims are to (1) Evaluate how stress impacts domains of behavior including (1a) executive function and (1b) opioid-seeking behavior; and (2) Determine whether rTMS stimulation attenuates (2a) executive dysfunction, (2b) stress-reactivity, and (2c) opioid-seeking in individuals with OUD not receiving treatment.
Eligibility criteria
Qualifiers
Meet DSM-5 criteria for OUD;
Age 21-60 yr;
Right handed;
Males and non-pregnant/non-lactating females;
Disqualifiers
Under influence of any substance during session;
Past 7-day use of illicit drugs other than opioids (except marijuana, which is legal in Michigan);
Urinalysis positive for cocaine metabolites, benzodiazepines, barbiturates, amphetamines or pregnancy;
Medical conditions prohibiting use of rTMS (e.g. seizure history; based on rTMS screening questionnaire);
Trial design
Treatments tested in this trial
- Yohimbine + Hydrocortisone
- Active rTMS
- Placebo
- Sham rTMS
Treatment groups
20 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov