Efficacy and Safety of JMT101 Combined Wth Docetaxel / HB1801 in Patients With Squamous Cell Non-Small Cell Lung Cancer

Trial statusNot yet recruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18-75
SponsorShanghai JMT-Bio Inc.

About this trial

This study is a phase II/III, randomized, controlled, open-label, multi-center study with safety run-in to evaluate the efficacy and safety of JMT101 combined with docetaxel/ HB1801 in Patients with Squamous cell non-small cell lung cancer (sqNSCLC).

Eligibility criteria

Qualifiers

Age ranged from 18 to 75 years old (inclusive), regardless of gender;

Pathological diagnosis as sqNSCLC, with EGFR highly expressed, without other driver genes

Tumor tissue available for central laboratory testing;

Disease progression after prior anti PD-1/PD-L1 and platinum containing chemotherapy

Disqualifiers

Previously used anti EGFR, or docetaxel;

Central nervous system metastasis or meningeal metastasis;

Patients with high risk of bleeding due to tumor invasion of important arteries;

Uncontrolled or requiring repeated drainage of pleural effusion, pericardial effusion, or abdominal effusion;

Trial design

Treatments tested in this trial

  • JMT101
  • docetaxel
  • HB1801

Treatment groups

534 Participants
are divided into 3 treatment groups

Locations

This trial has no locations

Sponsors and collaborators