This study aims to investigate the efficacy and safety of Sintilimab combined with FOLT versus Sintilimab combined with SOX in patients with locally advanced gastric cancer. The research design is intended to observe the comparison of conversion therapy effects, disease-free survival, R0 resection rate, and safety evaluation between the two groups.
1. Age >=18 years and <100 years.
2. Diagnosed with locally advanced gastric cancer.
3. Eastern Cooperative Oncology Group ECOG PS score 0-1.
4. adoption of preoperative chemotherapy treatment and PD-1 antibody therapy.
1. Locally advanced unable to resect or metastatic tumors.
2. Patients with recurrence of residual gastric cancer
3. Patients refusing surgical resection after preoperative chemotherapy therapy.
4. Have received any anti-tumor therapy such as chemotherapy, radiotherapy, immunotherapy, etc., or have been more than 180 days since the last treatment.