Efficacy and Safety of the RD Regimen(Lenalidomide, Dexamethasone) for Rosai-Dorfman Disease

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences

About this trial

In patients with Rosai-Dorfman disease (RDD), a treatment regimen of lenalidomide combined with dexamethasone is planned to be used.

Eligibility criteria

Qualifiers

Definitively diagnosed adult RDD patients;

Aged between 18 and 80 years;

Treatment-naive or refractory/relapsed;

ECOG performance status score ≤ 2;

Disqualifiers

Subjects who have undergone major surgery within 4 weeks prior to the first dose of the study;

Subjects who have received radiotherapy within 4 weeks prior to the first dose of the study;

Subjects with a history of myocardial infarction within the past year;

Patients with New York Heart Association (NYHA) Class 3 or 4 congestive heart failure, or a history of NYHA Class 3 or 4 congestive heart failure;

Trial design

Treatments tested in this trial

  • Lenalidomide
  • Dexamethasone

Treatment groups

40 Participants
are divided into 1 treatment group