Efficacy and Safety of Zuberitamab Combined with Bendamustine, Followed by Monotherapy Maintenance, in Treatment-naïve Follicular Lymphoma

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorSun Yat-sen University

About this trial

This is a prospective, single-arm, multicenter, phase ll clinical trial to evaluate the efficacy and safety of Zuberitamab and Bendamustine combination treatment in treatment-naïve follicular lymphoma patients.

Eligibility criteria

Qualifiers

Voluntary signing of informed consent.

Age ≥ 18 years, no gender restriction.

Histologically confirmed follicular lymphoma (grades 1-3a), CD20 positive by immunohistochemistry.

No prior systemic treatment for FL.

Disqualifiers

History of allergy to any component of monoclonal antibodies or investigational drugs.

Central nervous system involvement.

History of previous malignant tumors.

Clinically significant cardiac or pulmonary diseases.

Trial design

Treatments tested in this trial

  • Zuberitamab
  • Bendamustine

Treatment groups

50 Participants
are divided into 1 treatment group

Sponsors and collaborators

Sun Yat-sen University

Lead sponsor

Gansu Cancer Hospital

Collaborator

Ganzhou Cancer Hospital

Collaborator

Fifth Affiliated Hospital, Sun Yat-Sen University

Collaborator

Fifth Affiliated Hospital of Guangzhou Medical University

Collaborator