Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancer

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorThe First Affiliated Hospital of Zhengzhou University

About this trial

This study is a single-arm, prospective, open-label observational clinical study to evaluate the efficacy and safety of Bevacizumab combined with Oxaliplatin and TAS-102 in patients with advanced unresectable rectal cancer.

Eligibility criteria

Qualifiers

age: ≥18 years and ≤75 years;

ECOG score 0~1 points;

advanced colorectal cancer patients

According to RECIST1.1 criteria, there is at least one measurable target lesion, and tumor imaging evaluation is performed within 28 days before the first dose;

Disqualifiers

Patients who have received first-line standard therapy;

Previous antitumor therapy or radiation therapy for any malignant tumor;

concurrently receiving anti-tumor therapy in other clinical trials, including endocrine therapy, bisphosphonate therapy, or immunotherapy;

Has undergone major surgical procedures not related to colorectal cancer within 4 weeks prior to enrollment, or the patient has not fully recovered from such surgical procedures;

Trial design

Treatments tested in this trial

  • Bevacizumab combined with Oxaliplatin and TAS-102

Treatment groups

20 Participants
are divided into 1 treatment group

Locations

This trial has no locations