Evaluating the Impact of 18F-FDG-PET-CT on Risk Stratification and Treatment Adaptation for Patients with Muscle Invasive Bladder Cancer

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Ghent

About this trial

Evaluate the impact of 18F-FDG-PET-CT on the staging of patients with muscle invasive bladder cancer. Based on the results of 2 18F-FDG-PET-CT's patients are stratified in non-metastatic, oligometastatic and polymetastatic bladder cancer patients and the treatment is adapted accordingly to improve overall survival.

Eligibility criteria

Qualifiers

Histopathology-proven MIBC on TURb or ≥ T3 on conventional imaging treated with MIBC radical treatment

T1-4 N0-3 M0 MIBC on conventional imaging (thoracic CT and abdominopelvic CT/ MRI)

Age > 18 years

WHO 0-2

Disqualifiers

Presence of distant metastasis on conventional imaging (thoracic CT and abdominopelvic CT/ MRI)

Refusal of or having contraindications to 18F-FDG-PET-CT

Refusal of MDT or immunotherapy

Prior radiotherapy unabling MDT

Trial design

Treatments tested in this trial

  • Metastasis directed therapy (MDT)
  • Immunotherapy
  • Standard of care

Treatment groups

156 Participants
are divided into 3 treatment groups

Sponsors and collaborators

University Hospital, Ghent

Lead sponsor

Kom Op Tegen Kanker

Collaborator