Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Maryland, Baltimore
About this trial
The purpose of this research study is to find out if semaglutide is safe and well tolerated in adults with cocaine use disorder who do and do not have human immunodeficiency virus (HIV). Participants will complete a screening process and if you are able to participate, you will be assigned to one of two treatment groups: semaglutide or placebo.
Participants will:
* Visit the clinic once a week for semaglutide or placebo injections * Visit the clinic once every two weeks for labwork, assessments and/or surveys * If consented to optional MRI's, complete two MRI's
Eligibility criteria
Qualifiers
At least 18 years old
Meet criteria for CUD according to the Diagnostic and Statistical Manual Version 5
Used cocaine at least 7 out of the past 14 days
Body Mass Index between 20 - 50 kg/m2
Disqualifiers
Triglycerides > 500 mg/dL
History of gall bladder disease
Personal or family history of medullary thyroid carcinoma, or patients with a history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
History of diabetic retinopathy
Trial design
Treatments tested in this trial
- Semaglutide
- Placebo
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Maryland, Baltimore
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Source ClinicalTrials.gov