Exercise to Improve Brain Health in Older African Americans
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age60+
SponsorRutgers, The State University of New Jersey
About this trial
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.
Specifically, the main question\[s\] it aims to answer are:
* What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization? * What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization? * Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk?
Participants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.
Eligibility criteria
Qualifiers
self-identify as either African American or Black;
be age 60 or older;
able to speak, read, and understand English;
available over the study period; independently ambulatory (i.e., not needing a wheelchair, walker, or cane);
Disqualifiers
color-blindness (because some of our tasks utilize color as a cue);
any diagnosed neurological disorder (including headaches and peripheral neuropathy); diagnosed or self-reported non-neurological conditions that likely affect MTL outcomes, such as, major depressive disorder (or a Geriatric Depression Scale-Short Form score ≥ 5), schizophrenia, delusional disorder, schizoaffective disorder or significant psychiatric symptoms that could impair the completion of the study (e.g., psychosis), substance-related and addictive disorders (or treatment in past five years), chemotherapy or radiation treatment for cancers, planning to undergo general anesthesia during the study period;
exercise contraindications, such as, orthopedic complications, myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year, current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thrombosis (DVT) or another cardiovascular event, and uncontrolled hypertension with resting systolic or diastolic blood pressures > 180/110 mmHg.
Trial design
Treatments tested in this trial
- Cardio-Dance Fitness
- Strength, Flexibility & Balance
Treatment groups
280 Participants
are divided into 2 treatment groupsSponsors and collaborators
Rutgers, The State University of New Jersey
Lead sponsor
Göteborg University
Collaborator
University of California, Irvine
Collaborator
Source ClinicalTrials.gov