Fecal Microbiota Transplantation for Irritable Bowel Syndrome
Trial statusRecruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18-75
SponsorGuangzhou First People's Hospital
About this trial
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome. FMT has a higher cure rate than standard antibiotic treatment for recurrent Clostridium difficile infections,and shows promising results in Inflammatory bowel disease（IBD）.However, few studies have evaluated whether FMT is effective to treat Irritable bowel syndrome(IBS).The investigators propose to determine the efficiency and safety of FMT in patients with Irritable bowel syndrome.
Eligibility criteria
Qualifiers
Be able to give written informed consent.
Males and females aged >18 and <75
Have IBS as defined by the Rome IV criteria
Disqualifiers
pregnant or having a follow-up of less than 6 months;
unable to give informed consent;
suffering from other severe disease ,including liver and kidney failure, cancers, intestinal diseases, inflammatory bowel disease, C difficile infection;
unable to undergo endoscopy.
Trial design
Treatments tested in this trial
- fecal microbiota transplantation
- Infusion of sham
- probiotics, antibiotics or antidepressants
Treatment groups
120 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov