Fecal Microbiota Transplantation for Ulcerative Colitis
Trial statusRecruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18-65
SponsorGuangzhou First People's Hospital
About this trial
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome. Fecal microbiota transplantation has been used for several disease，but the efficacy of ulcerative colitis(UC) by fecal microbiota transplantation needs to be further explored.The investigators propose to determine the efficiency and safety of FMT in patients with ulcerative colitis(UC).
Eligibility criteria
Qualifiers
Active, moderate to severe severity (Mayo score more than 6)
Safety using history of 5-ASA
Able to undergo endoscopy examination
Disqualifiers
Antibiotic using in 7 days
High risk of toxic megacolon
Colon cancer or neoplasia in pathophysiology
Other severe diseases (eg: cardiovascular, respiratory, gastroenteral and kidney diseases)
Trial design
Treatments tested in this trial
- Fecal microbiota transplantation
- Infusion of Saline
- 5-Aminosalicylic acid(5-ASA) and/or Prednisone
Treatment groups
120 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov