Fluorescence Lymph Node Mapping for Colon Cancer Surgery

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age19-85
SponsorPusan National University Yangsan Hospital

About this trial

Fluorescence-guided surgery using indocyanine green can visualize the complex and diverse lymph node drainage structures for each patient and help determine the extent of dissection of the D3 lymph node tailored to the patient. However, since fluorescence lymph node mapping (FLNM) is still being conducted only at some institutions for research purposes and is limited to reporting the results of small-scale studies of patients, a large-scale multi-center study was conducted to verify the clinical-oncological effects of FLNM. Research is needed.

Therefore, this study used real-time fluorescence lymph node mapping (FLNM) to determine the extent of D3 lymph node dissection when performing right hemicolectomy and D3 lymph node dissection in patients with locally advanced right-sided colon cancer and to safely remove extensive lymph nodes. We aim to evaluate whether the dissection procedure is safe and beneficial in terms of clinical oncology.

Eligibility criteria

Qualifiers

Patients who over 19 years old, Under 85 years old

Patient with locally advanced right colon cancer requiring D3 lymphadenectomy

Colon cancer patients diagnosed with clinical stage cT3-4 N0 or cTany N1-2 before surgery

Patient with right-sided colon cancer located in the cecum, ascending colon, flexure colon, and proximal transverse colon.

Disqualifiers

Patients with a history of allergy or side effects to sodium iodine

Patients with colon cancer who have distant or peritoneal metastases

Patients requiring emergency surgery due to colon obstruction or colon perforation

Patients with inflammatory bowel disease not controlled by drug treatment

Trial design

Treatments tested in this trial

  • Indocyanine green (ICG) injection for intraoperative lymph node imaging
  • Standard Right Hemicolectomy (Non-ICG)

Treatment groups

186 Participants
are divided into 2 treatment groups