Habitat Escalated Adaptive Therapy (HEAT), With Neoadjuvant Radiation for Soft Tissue Sarcoma

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorH. Lee Moffitt Cancer Center and Research Institute

About this trial

The purpose of the study is to utilize radiomic images to precisely locate areas of tumor that can be treated with dose escalation radiation therapy.

Eligibility criteria

Qualifiers

Provision of signed and dated informed consent form

Stated willingness to comply with all study procedures and availability for the duration of the study

For women of childbearing potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 52 weeks after the end of radiation.

For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner 52 weeks after radiation.

Disqualifiers

Contraindications to an MRI

Positive urine pregnancy test

Gross total excision of primary STS, including an unplanned excision

Superficial sarcoma located primarily in the subcutaneous or cutaneous tissue

Trial design

Treatments tested in this trial

  • Intensity Modulated Radiation Therapy (IMRT)
  • MRI

Treatment groups

43 Participants
are divided into 1 treatment group

Sponsors and collaborators