Amyotrophic Lateral Sclerosis (ALS) is a nervous system disease that causes muscle weakness and rapidly progresses to the loss of mobility and functionality. Studies suggest that High-Definition Transcranial Direct Current Stimulation (HD-tDCS) is a technique for modulating motor cortical hyperexcitability. However, evidence on the use of HD-tDCS as a neuromodulator of the diaphragmatic motor cortex in people with ALS is inconclusive.
Both sexes; diagnosis of ALS according to the revised El Escorial criteria;
Age between 18 and 80 years;
Forced Vital Capacity greater than 50% of predicted;
Sniff nasal inspiratory pressure greater than 40 cmH2O;
Subjects who are unable to understand or perform any of the study procedures;
Subjects who do not agree to participate or voluntarily request withdrawal from the study at any time;
Subjects with cardiac, respiratory, or musculoskeletal comorbidities;
Subjects using invasive mechanical ventilation;
Universidade Federal do Rio Grande do Norte
Lead sponsor
Financiadora de Estudos e Projetos
Collaborator