High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy

Trial statusRecruiting
Trial phasePhase 2, Phase 3
Trial typeInterventional
Biological sexAll
Age18+
SponsorRigshospitalet, Denmark

About this trial

The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.

The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale

Eligibility criteria

Qualifiers

Age ≥ 18 year

Able to understand written and spoken Danish language

PCS ≥20

Signed written informed consent form.

Disqualifiers

Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids.

Individuals with diabetes requiring insulin treatment.

Pregnant or breastfeeding patients.

Patients with known allergies to the study drug.

Trial design

Treatments tested in this trial

  • Dexamethasone

Treatment groups

80 Participants
are divided into 2 treatment groups

Sponsors and collaborators