HPV DNA-Guided Radiotherapy De-intensification of Head and Neck Squamous Cell Carcinoma
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Virginia
About this trial
The study will evaluate the safety and effectiveness of a lower than standard dose of radiation for definitive or adjuvant treatment of head and neck squamous cell carcinomas.
Eligibility criteria
Qualifiers
Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, ≥ 18 years of age
Pathologically proven diagnosis of squamous cell carcinoma of the oropharynx of any AJCC 8th edition stage.
Disqualifiers
Evidence of distant metastatic disease
Prior history of radiotherapy to the head and/or neck
Had surgery for oropharyngeal cancer within 8 months of enrollment unless it was an incomplete oncologic surgery. Participant is eligible if the gross tumor was not completely removed.
Diagnosis of T3-4 and/or N+ disease with no plans to receive concurrent chemotherapy.
Trial design
Treatments tested in this trial
- Radiation Therapy
Treatment groups
90 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov