The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg).
The main question it aims to answer is: will patients who are randomly assigned to the high 24 mg maintenance dose, as compared to patients randomly assigned to the standard 16 mg maintenance dose, have improved retention in buprenorphine treatment (primary outcome), improved treatment response based on use of non-prescribed opioids (secondary outcome), decreased opioid cravings (secondary outcome), and decreased risk of fatal and non-fatal opioid overdose (exploratory outcome).
English-speaking
Age 18 years-old or older
Identified by the treating physician as having moderate to severe opioid use disorder (OUD)
Initiating or continuing buprenorphine for treatment of opioid use disorder
Previous enrollment in the trial
Incarcerated or in police custody*
Pregnant
Live outside of Rhode Island (RI)
Rhode Island Hospital
Lead sponsor
Brown University
Collaborator