Impact of Dapagliflozin in Anemic Chronic Kidney Disease Patients
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorMansoura University
About this trial
Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, primarily used in the management of type 2 diabetes mellitus. Emerging research suggests that SGLT2 inhibitors may offer additional benefits, including reducing the risk of cardiovascular events and renal complications. Post hoc analyses of previous clinical trials have shown that patients treated with SGLT2 inhibitors exhibited higher levels of hemoglobin and hematocrit compared to those in the control group. These findings suggest that dapagliflozin's ability to elevate hemoglobin levels could potentially be utilized for the treatment of anemia in patients with chronic kidney disease.
Eligibility criteria
Qualifiers
Adults aged ≥ 18 years with CKD stage III or IV.
Patients with anemia of CKD and a hemoglobin level < 11.5 g/dL
Patients are receiving erythropoiesis-stimulating agent therapy.
Disqualifiers
Anemia due to causes other than chronic kidney disease, such as pernicious anemia, thalassemia, sickle cell anemia, or myelodysplastic syndromes.
Patients with severe ketosis, diabetic coma, severe infection, perioperative complications, or severe trauma.
Patients with acute heart failure, acute myocardial infarction, or stroke occurring within 6 months before enrollment in the trial.
Patients with current malignancies or a history of malignancy within the past 2 years.
Trial design
Treatments tested in this trial
- Dapagliflozin (DAPA)
- Erythropoiesis Stimulating Agent
Treatment groups
80 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov