This study aims to elucidate the regression effects of neoadjuvant chemotherapy combined with immunotherapy and adjuvant therapy in locally advanced MSS colon cancer.
Age ≥18 years old and ≤75 years old.
Pathologically diagnosed MSS or pMMR-type colon adenocarcinoma.
The lower edge of the tumor is more than 12cm from the anus as measured by colonoscopy and the lower edge of the tumor cannot be directly palpated during rectal examination.
Enhanced CT stage T3/4 or T1-4N+ without multiple primary tumors or distant metastasis.
Refused to participate in this study.
Multifocal colorectal cancer.
History of malignant tumors, except for basal cell carcinoma, papillary thyroid carcinoma, and various in situ cancers.
Cannot tolerate chemotherapy, such as but not limited to bone marrow suppression.