Iparomlimab/Tuvonralimab Injection Plus CCRT in LACC

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-75
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences

About this trial

This study is a clinical study to evaluate the safety and efficacy of Iparomlimab/Tuvonralimab Injection (QL1706, a Bifunctional Mabpair Product of Anti-PD-1 and Anti-CTLA-4 Antibodies) in Combination With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer.

Eligibility criteria

Qualifiers

Informed consent.

Female patients aged ≥18 years and ≤ 75 years at time of inform consent signature

Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

Expected survival ≥ 3 months

Disqualifiers

Cervical cancer of other histology (e.g., neuroendocrine carcinoma, sarcoma)

Evidence of distant metastasis

Prior total hysterectomy (subtotal or cervical-sparing surgery allowed)

Unable or unwilling to receive brachytherapy

Trial design

Treatments tested in this trial

  • Iparomlimab/Tuvonralimab
  • Cisplatin
  • Brachytherapy and External Beam Radiotherapy

Treatment groups

30 Participants
are divided into 2 treatment groups