ConditionLOCALLY ADVANCED CERVICAL CANCERS
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-75
SponsorCancer Institute and Hospital, Chinese Academy of Medical Sciences
About this trial
This study is a clinical study to evaluate the safety and efficacy of Iparomlimab/Tuvonralimab Injection (QL1706, a Bifunctional Mabpair Product of Anti-PD-1 and Anti-CTLA-4 Antibodies) in Combination With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer.
Eligibility criteria
Qualifiers
Informed consent.
Female patients aged ≥18 years and ≤ 75 years at time of inform consent signature
Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
Expected survival ≥ 3 months
Disqualifiers
Cervical cancer of other histology (e.g., neuroendocrine carcinoma, sarcoma)
Evidence of distant metastasis
Prior total hysterectomy (subtotal or cervical-sparing surgery allowed)
Unable or unwilling to receive brachytherapy
Trial design
Treatments tested in this trial
- Iparomlimab/Tuvonralimab
- Cisplatin
- Brachytherapy and External Beam Radiotherapy
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov