The main objective of this pilot study is to evaluate at D9 the evolution of BPD symptoms' intensity(scale BSL-23) in severe BPD patients, after two Ketamine infusions (0.5mg/kg at H0 and H24). The intervention is combined with the first level standard of care : Good Psychiatric Management (GPM). Patients are followed up to 3 months by regular visits conducted by a psychiatrist. Secondary outcomes are monitored including BPD symptoms at different times, suicidal ideation, depressiv symptoms, healthcare use and adverse effects.
Adult patient aged 18 to 65 years
Fluent in French
Person affiliated with or receiving social security benefits.
Diagnosis of borderline personality disorder established according to the DSM-5 MINI criteria (5 out of 9 criteria)
Personal history of an acute psychotic episode or chronic psychotic disorder
Personal history of a manic or hypomanic episode
Family history (first-degree relatives) of a psychotic disorder
Current severe depressive episode