Letrozole and Misoprostol for Early Pregnancy Loss Management
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18+
SponsorUniversity of Pennsylvania
About this trial
A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early pregnancy loss in a US population. Patients will be followed to assess efficacy of this treatment regimen, as well as additional interventions needed, side effects, adverse events, and patient acceptability.
Eligibility criteria
Qualifiers
Able to participate in the informed consent process and provide a signed and dated consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
Access to working mobile phone
English-speaking
Disqualifiers
Incomplete or inevitable abortion
Contraindication of allergy to letrozole or misoprostol
Unable to return for clinic-based follow-up
Twin or multiple pregnancy
Trial design
Treatments tested in this trial
- Letrozole
- Misoprostol
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov