Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age10+
SponsorMansa

About this trial

The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY).

The investigators are interested in better understanding the way that this drug affects the metabolism and hormone levels of a person with MODY. Many people with MODY report having gastrointestinal (GI) issues such as an upset stomach. Investigators also are interested in finding out if this drug will help with GI issues.

If liraglutide does help with this symptom of MODY, the investigators want to know why this happens. If this drug is effective for participants, the investigators will use participants cells to make human induced pluripotent stem cell (iPSC). This means that the investigators will use participant cells to create what are called stem cells, which are cells in the body that are able to be told what their job is. Investigators will use these cells to see what happens in gastrointestinal (GI) tract.

Eligibility criteria

Qualifiers

Diagnosis of MODY via genetic testing

HgbA1c >6.5%

Disqualifiers

History of anaphylaxis to GLP-1 receptor agonists

Already taking GLP-1 receptor agonists

on medications within the stimulant class

have had bariatric surgery

Trial design

Treatments tested in this trial

  • Liraglutide

Treatment groups

50 Participants
are divided into 1 treatment group

Sponsors and collaborators

Mansa

Lead sponsor

Children's Hospital Medical Center, Cincinnati

Sponsor institution