Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Kansas Medical Center
About this trial
The purpose of this study is to assess the efficacy of metformin to improve airway ion channel function in those with CF-related diabetes (CFRD)
Eligibility criteria
Qualifiers
Age >18 years with a prior diagnosis of CF.
Use of ivacaftor or elexacaftor/tezacaftor/ivacaftor or vanzacaftor/tezacaftor/deutivacaftor for 30 days prior to day 0
Insulin use
Hemoglobin A1C >6.5%
Disqualifiers
Prior lung or liver transplant
Use of supplemental oxygen
BMI <18
CF pulmonary exacerbation requiring hospitalization or intravenous antibiotics in the preceding 30 days
Trial design
Treatments tested in this trial
- Metformin Hydrochloride
Treatment groups
30 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov