Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorJohns Hopkins University
About this trial
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
Eligibility criteria
Qualifiers
Physician-diagnosed asthma on maintenance therapy
Not well-controlled asthma (ACT score <20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months)
Overweight or obesity: Body mass index ≥25kg/m2
Adult: Age ≥18
Disqualifiers
Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding
Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months
Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis
Active smoking or former smoker with ≥20 pack-year smoking history
Trial design
Treatments tested in this trial
- Metformin hydrochloride extended-release tablets
- Visually identical placebo Metformin hydrochloride extended-release tablets
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Johns Hopkins University
Lead sponsor
Baylor College of Medicine
Collaborator
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Temple University
Collaborator
Source ClinicalTrials.gov